Single-stage treatment of chronic osteomyelitiswith a new absorbable, gentamicin-loaded, calcium sulphate/hydroxyapatitebiocomposite
نویسندگان
چکیده
M. A. McNally, MD, FRCSEd, FRCS(Orth), Consultant in Limb Reconstruction Surgery, Honorary Senior Lecturer in Orthopaedic Surgery J. Y. Ferguson, MB, BCh(Hons), MEd, FRCS(Orth), Specialty Trainee in Orthopaedics A. C. K. Lau, MBBS, FRCSEd(Orth), Clinical Fellow in Limb Reconstruction M. Diefenbeck, MD, PhD, Honorary Consultant in Orthopaedic Surgery M. Scarborough, PhD, MRCP, FRCPath, Consultant in Infectious Diseases B. L. Atkins, MBBS, MA, MSc, FRCPath, FRCP, Consultant in Microbiology and Infectious Diseases A. J. Ramsden , MB, ChB, MD, FRCS (Plast), Consultant Plastic and Reconstructive Microsurgeon Nuffield Orthopaedic Centre, The Bone Infection Unit, Oxford University Hospitals Foundation NHS Trust, Oxford OX3 7HE, UK.
منابع مشابه
Calcium Hydroxyapatite Ceramic
Porous blocks of calcium hydroxyapatite ceramic were evaluated as delivery systems for the sustained release of antibiotics. We tested gentamicin sulphate, cefoperazone sodium, and fiomoxef sodium in powder form placed in a cylindrical cavity in calcium hydroxyapatite blocks, using in vitro studies of elution and in vivo studies in rats. Gentamicin sulphate gave a maximum concentration within t...
متن کاملIn Vitro Activity of Gentamicin-Loaded Bioabsorbable Beads against Different Microorganisms
Osteomyelitis is responsible for high treatment costs, long hospital stays, and results in substantial morbidity. Treatment with surgical debridement and antibiotic-impregnated Polymethylmetacrylate (PMMA) beads is the standard of care, providing high local but low serum antibiotic concentrations, thereby avoiding systemic toxicity. However, for several reasons, the beads require surgical remov...
متن کاملElution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads.
The in vitro release of vancomycin, teicoplanin, gentamicin and clindamycin from biodegradable calcium sulphate (CaSO(4)) carrier beads is described. All antibiotics showed prolonged release from the carrier beads, which was elevated during the first 24 h, with peak levels exceeding 2500 microg/bead. Doubling the antibiotic load of the beads revealed a more prolonged elution and a two-fold incr...
متن کاملAdult osteomyelitis: debridement versus debridement plus Osteoset T pellets.
This long-term retrospective study investigated the value of debridement versus debridement and Osteoset T antibiotic-loaded calcium sulphate pellets in the treatment of adult chronic osteomyelitis. Sixty-five patients were included in the study. The mean follow-up was 75 months (range: 36 to 334). Forty cases were treated by debridement, and 25 by debridement and Osteoset T. The healing rates ...
متن کاملSurgical treatment for 76 patients with posttraumatic osteomyelitis of the tibia
This study aimed to assess the methods and curative effect of surgical treatment for post-traumatic osteomyelitis of the tibia. From March 2005 to June 2012, a total of 76 patients (49 male patients and 27 female patients) with posttraumatic osteomyelitis of the tibia were enrolled. Among the 76 patients, 9 patients were treated with infection elimination and bone graft surgery of vancomycin-lo...
متن کامل